PhD-Position: FE Modelling of Knee Joints (Julius Wolff Institute, Berlin, Germany)

PhD-Position: FE Modelling of Knee Joints (Julius Wolff Institute, Berlin, Germany)

The successful candidate will have the opportunity to perform cutting edge science to improve patient care in a collaborative project of the Charité-Berlin and the ETH-Zürich, while working on a worldwide unique dataset that includes measurements of in vivo knee loading and kinematics. The research project “In vivo knee joint loading and kinematics – the interplay between movement and loading at the patello-femoral and tibio-femoral joints” aims to extend the understanding of the complex mechanical interactions in the knee joint by combining in vivo measurements with detailed computational modelling. The position entails the possibility to pursue a doctorate degree. The position is placed mainly in Berlin, a vibrant city that is very attractive to young people due its rich cultural life. Regular visits at the ETH-Zürich to combine the expertise in this collaborative project are also part of the position.

Your area of responsibility

  • Finite element modelling of the dynamic contact of a total knee
    prosthesis at the tibio-femoral and patello-femoral interfaces
  • Coupling of finite element models to musculoskeletal multibody
    models which provide boundary conditions, like forces and kinematics
  • Development of an automated pipeline to generate and simulate
    modified versions of a reference finite element model in a systematic
    process
  • Reconstruction of 3D joint kinematics from fluoroscopic image data
    using available tools and eventually extending them

Your profile

  • MSc degree (or equivalent) in mechanical engineering or in a
    related field
  • Experience in finite element modeling, preferably of dynamic
    contact problems in Abaqus.
  • Preferably experience in automated generation of finite element
    models and the aggregation of the simulation results
  • Preferably experience in registration of medical image data and
    image processing
  • Ideally general purpose and scientific programming skills in a
    common language like: C++, Python, Matlab, R.
  • General interest in musculoskeletal biomechanics and mechanical
    simulation
  • Good English skills (oral and written)
  • Highly motivated, flexible, curious to learn and able to work
    independently

The tariff classification will be done according to the personal
conditions of salary group 13 (65 %) of the tariff TV-Charité. You can
find our collective agreements (Tarifverträge) here:
https://www.charite.de/en/careers/employer_charite/

The candidate should be able to begin his employment by early fall 2019.
The fixed-term work contract will expire with the end of the project on
July 31, 2022.

Interested candidates should submit a motivational letter, CV, academic
transcript and references by July 31, 2019. Applications should be sent
to Dr. Adam Trepczynski (adam.trepczynski@charite.de).

Dr. Adam Trepczynski
Julius Wolff Institute
Charité – Universitätsmedizin Berlin
https://jwi.charite.de/en

Post-doctoral/PhD position

Post-doctoral/PhD position in the Chair of Applied Dynamics

at the Friedrich-Alexander-Universität Erlangen-Nürnberg

The position is part of a DFG-funded project ‘A mechano-geometric framework to characterize macromolecular ensembles’ at the interface of robotics and structural bioinformatics in collaboration with the Biosciences Division at SLAC National Accelerator Laboratory at Stanford University, and the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco, California, USA.

Proteins perform an enormous variety of cellular functions on a broad range of spatio-temporal scales. Experimental and computational advances have increasingly enabled atomically detailed insights into their structure and dynamics. However, the molecular mechanisms of protein function, and how those mechanisms are perturbed by (disease) mutations and ligand interactions remain poorly understood. In this project we will develop and apply efficient robotics-inspired computational methods to resolve and study molecular mechanisms, with a view to redirect protein function. This is a unique opportunity to join a world-class interdisciplinary research team with financial support for frequent travel between FAU and sunny California.

The project focuses on aspects of

  • kinematic/geometric modeling of proteins/nucleic acids
  • optimized conformational sampling and motion planning/control
  • protein design, data-driven modeling, and machine learning
  • integrating crystallography, cryo-EM, and other data sources.
  • opportunities to gain bench experience

The ideal candidate has obtained a MS degree (PhD preferred) in a quantitative discipline, like engineering, computational (bio-)physics or chemistry, applied mathematics, computer science, and an interest in structural biology. Proficiency in C++/Python, and fluency in English is required.

Representative publications:

Budday, Leyendecker, van den Bedem (2015) Geometric analysis characterizes molecular rigidity in generic and non-generic protein configurations. J. Mech. Phys. Solids 83:36-47

Budday, Leyendecker, van den Bedem (2018) Kinematic Flexibility Analysis: Hydrogen Bonding Patterns Impart a Spatial Hierarchy of Protein Motion. J. Chem. Inf. Model. 58:2108-2122

Dasgupta, Budday et al (2019) Cysteine modification can gate non-equilibrium conformational dynamics during enzyme catalysis. preprint at https://doi.org/10.1101/524751

 

For more information or to apply please contact:

Sigrid Leyendecker (sigrid.leyendecker@fau.de)

Henry van den Bedem (vdbedem@stanford.edu)

Human Perception of Verticality: Lateropulsion & Retropulsion in Neurological Disorders (10. Mai 2019)

Human Perception of Verticality: Lateropulsion & Retropulsion in Neurological Disorders

Webseite

Conference of the European Society of Biomechancis (ESB)

Conference of the European Society of Biomechanics – ESB
Vienna (07-10.07.2019)

DGfB 2019 – PROGRAM ONLINE!!

The 11th Conference of the German Society for Biomechanics (DGfB) will take place on the 03-05.04.2019 in Berlin.

The Program has been placed online!

Homepage of the ConferenceOnline Program

PhD Project / Research Engineer

PhD Project / Research Engineer

18634BR

GREAT BRITAIN – Exeter

Job Description and Requirements

Synopsys NE Ltd (https://www.synopsys.com/simpleware.html) invites applications for an Early Stage Researcher position (Doctoral Candidate) as part of the Rapid Biomechanics and Simulation for Personalized Clinical Design (RAINBOW) MCSA European Training Network. RAINBOW is funded under the European Union’s Horizon 2020 research and innovation program.

The post holder will be employed on a fixed term (36-month contract) and be principally based at the Synopsys-Simpleware offices in Exeter UK but will also be enrolled as a full time graduate student at Cardiff University (http://www.cardiff.ac.uk/) undertaking research towards a PhD degree award. The candidate will be expected to spend periods of time in Cardiff as well as with other partners in the consortium.

The post holder will develop numerical methods to simulate the deformations of soft-tissues in the context of computer-aided surgery. In particular, he/she will contribute to bridging the gap between advanced 3D imaging techniques and physics-based computer simulations in order to improve current capabilities in the area of computer-aided diagnostic and surgical planning. A thorough knowledge of software development is essential.

This is a full time (37.5 hours per week) position on a fixed term basis for a fixed-term of 36 months.

We offer a competitive salary for this position.

The closing date for this position has been extended to the 15th of October 2018. The original closing date was the 10th of September 2018.

Job description

Thanks to recent advances in medical imaging and computer tomography, medical surgery is undergoing a revolution. Surgeons have routinely access to 3D reconstructions of patient anatomy that help them perform diagnoses, plan their operations, and may even have access to real-time feedback during surgical operations. Within the RAINBOW MSCA network. The job holder will explore the processing of 3D image data to convert to Computer Aided Engineering Geometric Representations.

The Early Stage Researcher will carry out one or more of the following tasks throughout the project:

  1. Develop techniques for multi scale analysis of tissue structure from microstructure through to whole organ analysis. Bridging lengthscale.
  2. Develop techniques inverse modelling.

Other tasks you will carry out:

  • To write and maintain accurate records of the research being undertaken.
  • To prepare publications and research presentations with guidance and advice.
  • To communicate and present research results within the research group, at meetings, through research paper publications and other recognized avenues as appropriate.
  • To assist with the preparation of progress reports on research for funding bodies as required.
  • To contribute to the overall activities of the research team and ITN as required, including attending network training activities and participating in public outreach activities.
  • To provide technical advice in relation of the research and the techniques used to other staff members within the wider research team.
  • To take part in knowledge-transfer activities, including collaborative meetings with other research groups.
  • To ensure compliance with legal and regulatory requirements in respect of equality and diversity, data protection, copyright and licensing, security, financial and other University policies, procedures and codes as appropriate.
  • To take reasonable care for the health of yourself and of other persons who may be affected by your acts or omissions at work in accordance with the Health and Safety at Work Act 1974, EC directives and the University’s Safety, Health and Environment Policies and procedures and to cooperate with the University on any legal duties placed on it as the employer.
  • You may be asked to perform other duties occasionally which are not included above, but which will be consistent with the role.

Eligibility

  • ITN rules for recruitment state that only early stage researchers (ESR) in the first 4 years of their career can be appointed. Therefore the applicant must not have been awarded a PhD and their research experience must total ≤ 4 years at date of recruitment (counted from the diploma/degree that gives the right to embark in a doctoral degree).
  • ESR recruitment is also subject to the mobility rule: the researcher must not have lived or carried out his/her main activity (work, studies etc) in the UK for more than 12 months in the 3 years immediately prior to his/her recruitment. Short stays (e.g. holidays) are not taken into account. Researchers can be of any nationality.
  • The ESR will ideally commence PhD enrolment / employment in September 2018. In order to enroll on a PhD at Cardiff University, the researcher will need to be able to provide evidence of English language ability. See http://www.cardiff.ac.uk/study/international/english-language-requirements for details. The relevant certificate/qualification does not need to have been obtained at the time of applying for this job but must be obtained before a formal offer of employment can be made.

Requirements

Essential Criteria

  1. A Bachelor’s degree in a relevant discipline – Computer Science, Mathematics or Engineering.
  2. Proven experience in computer programming (e.g. Matlab, Python, C++, C#, Java).
  3. Proven excellent oral and written communication skills with well-developed interpersonal skills.
  4. Ability to work effectively and collaboratively within a multidisciplinary team.
  5. A proven enthusiastic, self-motivated individual, willing to take part in personal skills training, international travel and public outreach activities.
  6. Experience of communicating to a variety of audiences through different media along with the ability to present confidently to academic and non-academic audiences at meetings and conferences.
  7. Demonstrated commitment to high quality research.

Desirable Criteria

  1. A Master’s degree in Computer Science, Mathematics or Engineering.
  2. Experience in using or developing computer image processing tools (segmentation, registration).
  3. Experience in the reporting and management of project progress.
  4. Demonstrable experience/competence in dissemination of research findings.
  5. A creative, innovative, team-working attitude.

 

PhD Project / Research Engineer

PhD Project / Research Engineer

18446BR

GREAT BRITAIN – Exeter

Job Description and Requirements

Synopsys NE Ltd (https://www.synopsys.com/simpleware.html) invites applications for an Early Stage Researcher position (Doctoral Candidate) as part of the Rapid Biomechanics and Simulation for Personalized Clinical Design (RAINBOW) MCSA European Training Network. RAINBOW is funded under the European Union’s Horizon 2020 research and innovation program.

The post holder will be employed on a fixed term (36-month contract) and be principally based at the Synopsys-Simpleware offices in Exeter UK but will also be enrolled as a full time graduate student at the University of Luxembourg (https://wwwen.uni.lu/) undertaking research towards a PhD degree award. The candidate will be expected to spend periods of time in Luxembourg as well as with other partners in the consortium.

The post holder will develop numerical methods to simulate the deformations of soft-tissues in the context of computer-aided surgery. In particular, he/she will contribute to bridging the gap between advanced 3D imaging techniques and physics-based computer simulations in order to improve current capabilities in the area of computer-aided diagnostic and surgical planning. A thorough knowledge of software development is essential.

This is a full time (37.5 hours per week) position on a fixed term basis for a fixed-term of 36 months.

We offer a competitive salary for this position.

​Applications for this position have been extended until the 15th of October 2018. Original closing date was the 10th of September 2018.

Job description

Thanks to recent advances in medical imaging and computer tomography, medical surgery is undergoing a revolution. Surgeons have routinely access to 3D reconstructions of patient anatomy that help them perform diagnoses, plan their operations, and may even have access to real-time feedback during surgical operations. Within the RAINBOW MSCA network. The job holder will explore the processing of 3D image data to convert to Computer Aided Engineering Geometric Representations.

The Early Stage Researcher will carry out one or more of the following tasks throughout the project:

  1. Develop techniques for the conversion of triangulated data into NURBS patches for the subsequent use of iso-geometric approaches. In particular focusing on generating conforming multipart models starting from image data.
  2. Statistical modelling- PCA.

Other tasks you will carry out:

  • To write and maintain accurate records of the research being undertaken.
  • To prepare publications and research presentations with guidance and advice.
  • To communicate and present research results within the research group, at meetings, through research paper publications and other recognized avenues as appropriate.
  • To assist with the preparation of progress reports on research for funding bodies as required.
  • To contribute to the overall activities of the research team and ITN as required, including attending network training activities and participating in public outreach activities.
  • To provide technical advice in relation of the research and the techniques used to other staff members within the wider research team.
  • To take part in knowledge-transfer activities, including collaborative meetings with other research groups.
  • To ensure compliance with legal and regulatory requirements in respect of equality and diversity, data protection, copyright and licensing, security, financial and other University policies, procedures and codes as appropriate.
  • To take reasonable care for the health of yourself and of other persons who may be affected by your acts or omissions at work in accordance with the Health and Safety at Work Act 1974, EC directives and the University’s Safety, Health and Environment Policies and procedures and to cooperate with the University on any legal duties placed on it as the employer.
  • You may be asked to perform other duties occasionally which are not included above, but which will be consistent with the role.

Eligibility

  • ITN rules for recruitment state that only early stage researchers (ESR) in the first 4 years of their career can be appointed. Therefore the applicant must not have been awarded a PhD and their research experience must total ≤ 4 years at date of recruitment (counted from the diploma/degree that gives the right to embark in a doctoral degree).
  • ESR recruitment is also subject to the mobility rule: the researcher must not have lived or carried out his/her main activity (work, studies etc) in the UK for more than 12 months in the 3 years immediately prior to his/her recruitment. Short stays (e.g. holidays) are not taken into account. Researchers can be of any nationality.
  • The ESR will ideally commence PhD enrolment / employment in September 2018.

Requirements

Essential Criteria

  1. A Bachelor’s degree in a relevant discipline – Computer Science, Mathematics or Engineering.
  2. Proven experience in computer programming (e.g. Matlab, Python, C++, C#, Java).
  3. Proven excellent oral and written communication skills with well-developed interpersonal skills.
  4. Ability to work effectively and collaboratively within a multidisciplinary team.
  5. A proven enthusiastic, self-motivated individual, willing to take part in personal skills training, international travel and public outreach activities.
  6. Experience of communicating to a variety of audiences through different media along with the ability to present confidently to academic and non-academic audiences at meetings and conferences.
  7. Demonstrated commitment to high quality research.

Desirable Criteria

  1. A Master’s degree in Computer Science, Mathematics or Engineering.
  2. Experience in using or developing computer image processing tools (segmentation, registration).
  3. Experience in the reporting and management of project progress.
  4. Demonstrable experience/competence in dissemination of research findings.
  5. A creative, innovative, team-working attitude.

 

TGCS 2019 Canmore (28-30.7.2019)

The 17th Biennial Symposium on Computer Simulation in Biomechanics

The 17th biennial symposium is a scientific and technical meeting for investigators and students in all areas of computer simulation in biomechanics, especially human movement, motor control, and robotics related to biomechanics.

The TGCS is a satellite symposium of the  ISB/ASB 2019 in Calgary.

Webseite

ISB/ASB 2019 Abstractdeadline (31.01.2019)

XXVII Congress of the International Society of Biomechanics (ISB2019)

Welcome to Calgary, Canada, for the XXVII Congress of the International Society of Biomechanics (ISB2019), held in conjunction with the 43rd Annual Meeting of the American Society of Biomechanics (ASB2019).

Webseite

16th CMBBE 2019 Abstractdeadline (15.02.2019)

CMMBE 2019: The 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering
and 4th Conference on Imaging and Visualization

New York, USA
14-16 August 2019

Website